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Journal: medRxiv
Article Title: Early Fc-effector antibody signatures impact COVID-19 disease trajectory
doi: 10.64898/2026.02.18.26346542
Figure Lengend Snippet: A) Heatmap of FcγR-binding antibody responses to SARS-CoV-2 S antigens in mild and severe COVID-19 patients. Binding activity of antibodies to FcγRs was measured for SARS-CoV-2 full-length S, S1 and S2 antigens at days 0, 3, 7, and 46 post-recruitment. Box-and-whisker diagrams showing (B) FcγR2AH and FcγR2AR-binding antibody responses (C) FcγR3AV and FcγR3AF-binding titers, (D) functional monocyte antibody-dependent cellular phagocytosis (ADCP) responses and (E) functional antibody-dependent neutrophil phagocytosis (ADNP) responses against SARS-CoV-2 full-length S, S1 and S2 antigens in mild and severe COVID-19 patients. Box indicates interquartile range (IQR, Q1-Q3), with horizontal line showing the median and vertical lines indicating minimum and maximum. Mann-Whitney U test was performed to compare differences between mild vs. severe patients at each time point. Statistical significance was considered when p ≤ 0.05. F) PCA of antibody responses according to day of recruitment (day 0: blue; day 3: red; day 7: green and day 46: purple). Empty circles represent mild cases, and filled circles represent severe cases. Ellipses show 95% confidence regions. G) Spider plot of the antibody landscape (IgG antibody titers, FcγR-binding activity and FcγR-effector functions) in mild and severe COVID-19 patients. Median percentile for each antibody feature is shown at each timepoint and for each SARS-CoV-2 S antigen.
Article Snippet: For the analysis of
Techniques: Binding Assay, Activity Assay, Whisker Assay, Functional Assay, MANN-WHITNEY